The U.S.Food and Drug Administration has issued a public health advisory about potential risks of taking certain migraine medications – triptans – together with certain antidepressants. The advisory states, “A life-threatening condition called serotonin syndrome may occur when triptans are used together with a SSRI or a SNRI.”

Serotonin syndrome occurs when the body has too much of serotonin, a chemical found in the nervous system. Serotonin syndrome may be more likely to occur when starting or increasing the dose of a triptan, SSRI or SNRI. Symptoms of serotonin syndrome may include:

  • restlessness
  • hallucinations
  • loss of coordination
  • fast heart beat
  • rapid changes in blood pressure
  • increased body temperature
  • overactive reflexes
  • nausea
  • vomiting
  • diarrhea

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